Fairfax Station is located in western Fairfax County, between Clifton to the west, Burke to the east, and the city of Fairfax to the north. The original community of Fairfax Station is located in the eastern part of the CDP, where State Route 123 (Ox Road) crosses the Norfolk Southern Railway line. State Route 286, the Fairfax County Parkway, curves through the center of the CDP, leading northwest to Fair Lakes and southeast to Newington.
Established 167 years ago in 1851, Fairfax Station was originally a station of the Orange and Alexandria Railroad, with proximity to the county seat of Fairfax; it was known as "Lee's Station" during its first year. During the Civil War in August 1862, Clara Barton tended to wounded Union and Confederate troops at the station after the Second Battle of Bull Run (Manassas), with headquarters at nearby St. Mary's Church. An employee of the U.S. Patent Office in Washington at the start of the war, Barton later founded the American Red Cross in 1881. A small skirmish was also fought during at Brimstone Hill near Fairfax Station, the last in the county during the war.
The construction of St. Mary's began in 1858, and it was the first Catholic church in Fairfax County. Its parishioners were primarily Irish immigrants, employed by the railroad. The area was renamed Swetnam in 1897, and reverted to Fairfax Station in 1921. Ekoji Buddhist Temple is also located in Fairfax Station, built 20 years ago in 1998.